We did this from 1997 until 2013. The Neocons are angry because we didn't go far enough and break up Russia in the 90s.
Let's just take a hypothetical and say that happened, and we managed to get all of Russia's nukes safely away from the warlords that arose after we neutered Russia. Now we have them disarmed and contained, and all is good forever, right?
That scenario is somewhat equivalent to what Israeal has been doing to the Palestinians for 70 years - and the Israelis are NEVER at peace with the Palestinians.
Gaza is the largest open air prison in the world. Russia is the largest country in the world. We can only expect that making Russia an open air prison like Gaza would result in - eventually - a huge and violent backlash.